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Objective: To assess the effect of testosterone replacement on these above-mentioned parameters in glucocorticoid-treated men. Methods: A placebo-controlled, double-blind, 2-way crossover trial, with 7 subjects each, was conducted in which the hormone replacement therapy was administered at baseline followed by testosterone (400 ng/ml) supplementation for 14 wk. The main outcome measures were the reduction in the total-body cholesterol of the subjects, the percent of change in the testosterone concentration, and the change in the sex hormone-binding globulin concentration of the subjects, both after treatment on the first trimester day before the implantation and on the 28th week after the last treatment, respectively. Results: The total testosterone concentration decreased from 0.38 ng/ml to 0.38 ng/ml by the end of the treatment, while the total-body cholesterol decreased from 1.02 mmol/liter to 0.94 mmol/liter. After treatment on the first trimester day before the implantation, the mean difference in free testosterone concentration was 6.3% (range = −1.7–11.9%). The mean change in the sex steroid-binding globulin concentration after treatment on the first trimester day before implantation was 3.1% (range = −4.3–4.8; p < 0.01). The changes in these parameters did not significantly differ between groups on the last assessment day, as compared with the last baseline measurement. CONCLUSIONS: At the end of 14 wk of the treatment, the treatment did not have any significant effect on any of them, but its effects on cholesterol levels and sex hormone-binding globulin concentration did have a slight effect on the subjects. Related Article: